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Metabolism is the most ancient and fundamental process in all living history. Metabolism is the combination of all chemical reactions that occur within cells, ensuring proper function and survival. As such, proper metabolic functioning is paramount for overall health. Through the lens of metabolism, the Hotamisligil Lab explores the basic mechanisms of metabolic and immuno-metabolic adaptations and how they play a causal role in obesity- and age-related diseases, the greatest threats to global public health. Through this approach, our research hopes to create pathways towards a disease-free life in a healthier world.