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Welcome to the Hotamışlıgil Lab
The Hotamışlıgil Lab studies innate adaptive pathways involved in metabolic health and diseases such as obesity, diabetes, hepatosteosis, lung and cardiovascular diseases. For the past 30 years, the lab has made important contributions to the field of “immunometabolism” or “metaflammation” studying the interactions between metabolic and immune responses as critical drivers of numerous chronic diseases. We also discovered novel lipid and peptide hormones that are critical for metabolic homeostasis and its pathologies. In the last decade, the lab has approached immunometabolism and homeostasis in two broad paths: organelle homeostasis and substrate metabolism in health and disease. Using biochemical, genetic, and physiological studies, the lab aims to convert its fundamental mechanistic discoveries into novel preventive, therapeutic solutions to today’s greatest threats to global human health such as obesity- and age-related chronic diseases.
Our Research
Lipid Metabolism, Hormones & Lipid Binding Proteins
Lipids play a central role in immunometabolic homeostasis and adaptations. We explore biologically active lipids and lipid hormones and the critical role of fatty acid binding proteins (FABPs) in lipid signaling, metabolic regulation, and pathologies associated with obesity and aging.
Organelle Homeostasis in Metabolism
Understand the essential functions of cellular organelles, especially the endoplasmic reticulum, in maintaining metabolic homeostasis and preventing disorders through their interactions and structural integrity.
Metaflammation & Immunometabolism
Delve into the intricate relationship between energy management, metabolism and immune response, highlighting how chronic metaflammation contributes to widespread metabolic diseases associated with obesity and aging.
