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The Hotamışlıgil Lab studies innate adaptive pathways involved in metabolic health and diseases such as obesity, diabetes, hepatosteosis, lung and cardiovascular diseases. For the past 30 years, the lab has made important contributions to the field of “immunometabolism” or “metaflammation” studying the interactions between metabolic and immune responses as critical drivers of numerous chronic diseases. We also discovered novel lipid and peptide hormones that are critical for metabolic homeostasis and its pathologies. In the last decade, the lab has approached immunometabolism and homeostasis in two broad paths: organelle homeostasis and substrate metabolism in health and disease. Using biochemical, genetic, and physiological studies, the lab aims to convert its fundamental mechanistic discoveries into novel preventive, therapeutic solutions to today’s greatest threats to global human health such as obesity- and age-related chronic diseases.